Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in podocytes | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 46 | 0.82 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6806
Sealed predictions
- ADAMTS19 in dopamine neurons, braak+0.06 (p 0.886) → +0.26 (p 0.500)receipt 6813
Swarm cases
receipt 6813: ADAMTS19 in dopamine neurons, braak
- power
- full sample +0.25 (p 0.315, n 18), 95% CI -0.24 to +0.64. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.27 (p 0.281, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.351, n 18). could be the mix.
- skeptic
- leave-one-out range +0.14 to +0.39, sign flips 0; without severely affected donors +0.25 (p 0.315, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ADAMTS19 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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