Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (enterocytes) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 2 Parkinson's papers of 151 | 0.85 |
| pathways Reactome | 3 pathways; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 7261
Sealed predictions
- ACY1 in dopamine neurons, braak+0.42 (p 0.258) → -0.58 (p 0.102)receipt 7268
Swarm cases
receipt 7268: ACY1 in dopamine neurons, braak
- power
- full sample -0.22 (p 0.374, n 18), 95% CI -0.62 to +0.27. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.12 (p 0.640, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.12 (p 0.640, n 18). could be the mix.
- skeptic
- leave-one-out range -0.41 to -0.13, sign flips 0; without severely affected donors -0.22 (p 0.374, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ACY1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts