Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.21 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 75 Parkinson's papers of 14,640 | 0.43 |
| pathways Reactome | 5 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 1995
Sealed predictions
- ACE2 in dopamine neurons, braak+0.47 (p 0.204) → +0.44 (p 0.240)receipt 2002
Swarm cases
receipt 2002: ACE2 in dopamine neurons, braak
- power
- full sample +0.36 (p 0.137, n 18), 95% CI -0.12 to +0.71. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.45 (p 0.063, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.49 (p 0.041, n 18). not the mix.
- skeptic
- leave-one-out range +0.28 to +0.50, sign flips 0; without severely affected donors +0.36 (p 0.137, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ACE2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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