Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.23 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 22 Parkinson's trials, 2 stopped | 0.93 |
| literature PubMed | 6 Parkinson's papers of 16,077 | 0.74 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1869
Sealed predictions
- ABO in dopamine neurons, braak-0.48 (p 0.195) → +0.19 (p 0.630)receipt 1876
Swarm cases
receipt 1876: ABO in dopamine neurons, braak
- power
- full sample -0.08 (p 0.767, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.08 (p 0.754, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.12 (p 0.646, n 18). could be the mix.
- skeptic
- leave-one-out range -0.20 to +0.04, sign flips 4; without severely affected donors -0.08 (p 0.767, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ABO in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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